BIG 19

Concurrent session II




From 16:00 to 17:00 in rooms 2311 and 2314, UBC Nest

Robert Hancock,  OC, OBC, FRSC     University of British Columbia

Robert Hancock, OC, OBC, FRSC
University of British Columbia

“How to deal with biofilms: A common, adaptive multidrug resistance bacterial lifestyle” | Room 2314

The inexorable increase in multidrug resistant infections combined with a decrease in new antibiotic discovery and the lack of compounds to treat recalcitrant chronic biofilm infections is creating a potential crisis in human medicine. Biofilms are the main growth form of the bacteria in the environment, cause two thirds of infections, are very difficult to treat being (adaptively) resistant to almost all antibiotics, and there are no licensed treatments. Thus it is imperative to consider alternatives to conventional antibiotics for treating infections. I will discuss our development of a class of broad-spectrum peptides, based on a template of natural cationic host defence (antimicrobial) peptides, that act against biofilms, formed by many bacteria, both in vitro and in vivo, and are highly synergetic with conventional antibiotics.

"The Darwinian Disease: Evolutionary Biology and Genetics of Cancer" | Room 2311

Carcinogenesis is a somatic evolutionary process. As a result, the concepts and tools of evolutionary biology are central to studying it. But how do they help? Predominantly by changing how people think about the disease: in terms of variation, natural selection, trade-offs, conflicts, and evolutionary mismatches. Bioinformatic analyses and genomic data collection are of key importance in applying evolutionary thinking and tools to collecting data and treating patients. In this workshop, we will discuss how.

Bernard Crespi, PhD  Simon Fraser University

Bernard Crespi, PhD
Simon Fraser University